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  • Title: Metabolism of (5E)-6a-carbaprostaglandin I2 by rhesus monkey lung 15-OH prostaglandin dehydrogenase.
    Author: McGuire JC, Morton DR, Brokaw FC, Sun FF.
    Journal: Prostaglandins; 1981 Apr; 21(4):609-14. PubMed ID: 7019975.
    Abstract:
    (5E)-6a-Carbaprostaglandin I2 (carbacyclin) was oxidized to (5E)-15-dehydro-6a-carbaprostaglandin I2 (15-dehydrocarbacyclin) by partially purified rhesus monkey lung prostaglandin dehydrogenase (PGDH). The (5E-15-dehydro-6a-carbaprostaglandin I2 was isolated by preparative thin-layer chromatography and identified by gas chromatography-mass spectrometry. A Lineweaver-Burke plot gave an apparent Km value of 2.9 microM and a Vmax of 35.7 nmoles carbacyclin oxidized/mg protein/min. These values are similar to previously reported Km and Vmax values for PGI2 and PGE1.
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