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  • Title: Effects of antibacterial agents on the elimination of 32P-labelled Escherichia coli by human polymorphonuclear cells (PMN).
    Author: Melby K, Midtvedt T.
    Journal: Acta Pathol Microbiol Scand B; 1981 Apr; 89(2):129-31. PubMed ID: 7020339.
    Abstract:
    Eight antibacterial agents, cephalothin, colistin, doxycycline, erythromycin, gentamicin, chloramphenicol, oxytetracycline and trimethoprim were studied in a phagocytic system using human polymorphonuclear cells (PMN) and a radio-labelled strain of Escherichia coli as test microbe. 100 micrograms/ml of either doxycycline or trimethoprim appeared to reduce the elimination of labelled products from the PMN. The effect of doxycycline was independent of heat-labile serum factors.
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