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  • Title: Inhibition of platelet aggregation with intravenous and oral administration of carboprostacyclin in man.
    Author: Karim SM, Adaikan PG, Lau LC, Tai MY.
    Journal: Prostaglandins Med; 1981 May; 6(5):521-7. PubMed ID: 7022510.
    Abstract:
    Intravenous infusion of carboprostacyclin, a chemically stable analogue of prostacyclin (PGI2) resulted in ex-vivo inhibition of ADP-induced platelet aggregation at doses that did not produce significant changes in blood pressure or heart rate. Oral administration of relatively large doses of this compound also inhibited ex-vivo ADP-induced platelet aggregation but this was accompanied by headache, facial flush, tachycardia and changes in blood pressure.
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