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  • Title: Synthesis of 1-methyl-2-phenylcarbamoylpyrazolidines as potential anticonvulsant agents.
    Author: Kornet MJ.
    Journal: J Pharm Sci; 1978 Oct; 67(10):1471-3. PubMed ID: 702307.
    Abstract:
    Lithium aluminum hydride reduction of 1,4-dimethyl-3-pyrazolidinone yielded 1,4-dimethylpyrazolidine. The latter compound and 1-methylpyrazolidine reacted with aryl isocyanates to produce 1-methyl-2-phenylcarbamoylpyrazolidines. Several of these adducts displayed significant anticonvulsant activity in the maximal electroshock seizure and pentylenetetrazol seizure threshold tests.
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