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  • Title: Deposition of IgA-dominant immune-complexes in muscular vessels from patients with IgA nephropathy.
    Author: Tomino Y, Nomoto Y, Endoh M, Sakai H.
    Journal: Acta Pathol Jpn; 1981 May; 31(3):361-5. PubMed ID: 7023184.
    Abstract:
    The emergence of immunoglobulin depositions in muscular vessels from patients with IgA nephropathy was examined to determine whether the pathogenesis of IgA nephropathy was mediated by circulating IgA-dominant immune-complexes. Muscle biopsy specimens were obtained from the right flank at the same time of modified open renal biopsy. These biopsy samples were stained with fluorescein-conjugated anti human IgG, IgA, IgM, IgE, and C3 antisera. It was demonstrated that the depositions of IgA and/or C3 were observed in muscular vessels from some patients with IgA nephropathy. It is indicated that IgA nephropathy might be mediated by circulating IgA-dominant immune-complexes.
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