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  • Title: Renin responsiveness to furosemide in the homotransplanted kidney.
    Author: Lebel M, Lachance JG, Grose JH.
    Journal: Biomedicine; 1981 Jul; 35(3):81-4. PubMed ID: 7023561.
    Abstract:
    Plasma renin activity (PRA) was measured after repetitive furosemide stimulations in 16 normotensive homotransplanted patients who previously had bilateral nephrectomies. The percentage PRA response to furosemide was very low (34%) in the immediate period after transplantation, but increased progressively with time to a level after one year (111%) which was not statistically different from age and sex matched control subjects. A significant correlation was found between the percentage PRA increase and the number of weeks after transplantation (r = 0.48, P less than 0.01). These data indicate that the juxtaglomerular cell responsiveness to furosemide is quantitatively time dependent after transplantation, and it is a factor that should be considered in the evaluation of renin-angiotensin system in such patients.
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