These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of prazosin and oxprenolol on plasma renin activity and blood pressure in patients with essential hypertension.
    Author: Farsang C, Juhász I, Kapocsi J, Vajda L, Székács B.
    Journal: Cardiology; 1981; 67(3):164-71. PubMed ID: 7023672.
    Abstract:
    48 patients with normal-renin essential hypertension were treated with prazosin alone or in combination with oxprenolol. 1 h after a single dose of 2 mg prazosin tachycardia and a decrease in blood pressure developed. Renin activity in the peripheral plasma (PRA) increased from 1.04 +/- 0.15 to 2.64 +/- 0.20 ng AgT/ml/h. A 3-day treatment with 2 mg t.i.d. prazosin of 11 patients caused no further decrease in blood pressure, while PRA returned to the baseline level. Treatment for 3 days with 2 mg prazosin t.i.d. and 40 mg oxprenolol t.i.d. of 37 patients further decreased blood pressure as well as PRA. The increase in PRA after a single dose of prazosin could be related to the enhanced sympathetic activity. The decreased PRA after prazosin + oxprenolol therapy may be one of the factors responsible for the greater antihypertensive response to the combined therapy.
    [Abstract] [Full Text] [Related] [New Search]