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  • Title: Variability of anti-GBM binding in hereditary nephritis.
    Author: Jenis EH, Valeski JE, Calcagno PL.
    Journal: Clin Nephrol; 1981 Mar; 15(3):111-4. PubMed ID: 7023765.
    Abstract:
    Anti-GBM staining by indirect immunofluorescence microscopy was performed on renal biopsies from 64 patients with a variety of diseases in which no in vivo bound immunoglobulin or complement components were identified by direct immunofluorescence microscopy. The glomeruli of all of the entities examined bound anti-GBM antibodies except for four of nine cases of hereditary nephritis of the Alport-type. The absence of anti-GBM staining was found to correlate with the severity of GBM splitting identified by electron microscopy.
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