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  • Title: Irreversible inactivation of yeast glucose-6-P dehydrogenase by penicillin G.
    Author: Han PF, Mariam YH, Pollock SH, Matthews HW, Johnson J.
    Journal: Experientia; 1981 Jul 15; 37(7):687-9. PubMed ID: 7023963.
    Abstract:
    Yeast glucose-6-P dehydrogenase is irreversibly inactivated by penicillin G. Kinetic data show that 1 molecule of penicillin G reacts with each active unit when the enzyme is inactivated. The rate of inactivation increases greatly with increasing pH. This irreversible inactivation by penicillin G is largely prevented by pyridoxal-P, a reversible inactivator or this enzyme. Prior treatment of penicillin G with penicillinase totally abolishes its ability to inactivate the enzyme.
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