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  • Title: Effect of PGI2 infusion during long term extracorporeal circulation with membrane lung in sheep.
    Author: Uziel L, Agostoni A, Pirovano E, Pesenti A, Pelizzola A, Gattinoni L, Galmarini D.
    Journal: Int J Artif Organs; 1981 May; 4(3):142-5. PubMed ID: 7024139.
    Abstract:
    PGI2 plus very low dose of heparin was infused in 6 lambs connected for long term extracorporeal circulation with a membrane lung. Hemodynamic and hemostasis parameters were compared to those of a control group treated only with standard doses of heparin. PGI2 efficacy in inhibiting platelet aggregation and platelet fall was confirmed. A small platelet release, measured as antiheparin activity, was observed during all the by-pass, but did not influence platelet capacity of recovering when PGI2 effect dissolved. Heparin needed resulted less than a quarter of the quantity used for the control group. In our experimental conditions the hemodynamic changes were mainly limited to a decrease in diastolic blood pressure.
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