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  • Title: Cimetidine and fat malabsorption in children with cystic fibrosis.
    Author: Schöni M, Kraemer R, Rossi E.
    Journal: Helv Paediatr Acta; 1981 Sep; 36(4):359-69. PubMed ID: 7024207.
    Abstract:
    Under controlled clinical observation we administered Cimetidine (600 mg/m2/day) in 10 children with cystic fibrosis. All patients received identical diets (40% fat, 45% carbohydrate, 15% protein) as well as same standardized enzyme preparation (lyophilised whole pancreas). 3-day fecal fat and nitrogen excretion analyses were performed. After 6 days of Cimetidine therapy, an improvement of fat and nitrogen absorption could be detected in 5 patients. Statistical analysis of the group as a whole showed no improvement in fat absorption coefficients. We conclude that this drug therapy should only be recommended for routine clinical use after long-term trials have shown a real improvement of absorption.
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