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  • Title: Phenformin stimulation of insulin binding to human cultured lymphocytes.
    Author: Iwamoto Y, Goldfine ID.
    Journal: J Endocrinol Invest; 1981; 4(2):229-31. PubMed ID: 7024393.
    Abstract:
    The effects of the oral hypoglycemic agent, phenformin, were studied on the binding of 125I-insulin to its receptors in IM-9 human cultured lymphocytes. Three h after the addition of 5 microgram/ml of phenformin to these cells there was detectable stimulation of 125I-insulin binding; maximal effects were seen after 18 h. A detectable effect of phenformin was seen at 1 microgram/ml and maximal effects were seen at 5 microgram/ml. These studies demonstrate therefore than phenformin increases the binding of 125I-insulin to human cultured lymphocytes, and raise the possibility that phenformin could act in vivo to regulate insulin receptors.
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