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  • Title: Mutational specificity of the base analogue, 2-aminopurine, in Escherichia coli.
    Author: Persing DH, McGinty L, Adams CW, Fowler RG.
    Journal: Mutat Res; 1981 Aug; 83(1):25-37. PubMed ID: 7024792.
    Abstract:
    2-Aminopurine (2-AP) is a base analogue of adenine which mispairs with cytosine and causes base-pair substitutions of the transition type. By analyzing the reversion patterns of defined trpA alleles in Escherichia coli we confirm that 2-AP causes both A:T leads to G:C and G:C leads to A:T transitions with the former induced more frequently than the latter. We also find that 2-AP enhances transversions at 3 sites and frameshift mutations at 1 other site. It is unlikely that 2-AP can cause transversions and frameshifts solely by a mispairing mechanism. However, 2-AP-induced transversion and frameshift mutagenesis was not abolished by the presence of an inactive recA allele, indicating this mutagenic activity is not dependent upon recA-directed misrepair.
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