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  • Title: Effect of local urokinase on arterial occlusion of lower limbs.
    Author: Fiessinger JN, Aiach M, Capron L, Devanlay M, Vayssairat M, Juillet Y.
    Journal: Thromb Haemost; 1981 Jun 30; 45(3):230-2. PubMed ID: 7025340.
    Abstract:
    Sixty nine patients were treated with local intra-arterial urokinase (37,500 U/CTA. hr-1) for recent severe ischemia of lower limbs: 27 (40%) ultimately required amputation. The difference of amputation rate between the groups with and without thrombolysis was not significant (33% v. 42%). A biological study in 6 patients showed that local arterial plasminemia occurred in only 1 patient. Local urokinase does not strongly stimulate "endogenous" thrombolysis and enhances "exogenous" thrombolysis only very inconstantly. A better adaptation of urokinase dosage or the use of an agent with higher affinity for fibrin might improve the efficiency of local thrombolytic therapy.
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