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  • Title: The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
    Author: Joyce EM, Koob GF, Strecker R, Iversen SD, Bloom FE.
    Journal: Brain Res; 1981 Sep 28; 221(2):359-70. PubMed ID: 7025963.
    Abstract:
    Two stable analogues of enkephalin D-Ala2-Met5-enkephalinamide (DAMA) and D-Ala2,D-Leu5-enkephalin (DADLE) injected bilaterally into the ventral tegmental area (VTA) induced locomotion, characterized by bursts of morphine-like activity. The response of DADLE was blocked by systemic-alpha-flupenthixol (0.2 mg/kg) and naloxone (1 mg/kg). At higher doses of enkephalins in the VTA, stereotypy behaviour involving gnawing, became apparent. When injected bilaterally into the globus pallidus (GP), both analogues induced a dose-dependent increase in locomotor activity but stereotypy was not observed. The locomotor behaviour induced by DADLE was blocked by naloxone but not by alpha-flupenthixol. These results suggest that naloxone-sensitive opiate receptors modulate, at a number of different sites, the neural pathways involved in the expression of behavioural activity.
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