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  • Title: Genetic activity of vinylidene chloride in yeast.
    Author: Bronzetti G, Bauer C, Corsi C, Leporini C, Nieri R, del Carratore R.
    Journal: Mutat Res; 1981 Jun; 89(2):179-85. PubMed ID: 7027030.
    Abstract:
    Vinylidene chloride (VDC) was tested for its ability to induce both point mutation and mitotic gene conversion in a diploid strain (D7) of the yeast Saccharomyces cerevisiae in a suspension test with and without a mammalian microsomal activation system, and in the intrasanguineous host-mediated assay in mice. In suspension tests with D7, VCD was toxic but not genetically active without microsomal activation. When a mouse liver 10 000 X g supernatant was included in the suspension tests, dose-related increases in both point mutation and mitotic gene conversion were seen at survival levels greater than 50%, at doses of VCD above 20 mM. In the host-mediated assay, VDC induced both point mutation and mitotic gene conversion when recovered from the liver and kidneys after both acute and sub-acute dosing. Yeasts recovered from the lungs showed little, if any, increase in either point mutation or mitotic gene conversion.
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