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  • Title: Structure-function relationships in insulin.
    Author: Saunders DJ.
    Journal: Biosci Rep; 1981 Jun; 1(6):485-95. PubMed ID: 7028158.
    Abstract:
    A new interpretation of structure-function relationships in the insulin molecule is presented. Negative cooperativity is postulated to arise from a dimerization event occurring between two receptor-bound molecules. The receptor-binding surface of insulin can necessarily not involve residues involved in dimerization as has been generally accepted. Support for this interpretation is based on published data.
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