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  • Title: Comparison of simple sugar/salt versus glucose/electrolyte oral rehydration solutions in infant diarrhoea.
    Author: Clements ML, Levine MM, Cleaves F, Hughes TP, Caceres M, Aleman E, Black RE, Rust J.
    Journal: J Trop Med Hyg; 1981 Oct; 84(5):189-94. PubMed ID: 7029004.
    Abstract:
    In a randomized double-blind trial, infants with mild or moderate diarrhoeal dehydration were rehydrated orally either with a simple solution containing table sugar and salt (without potassium or bicarbonate) or with a complete glucose/electrolyte formula. All 32 given glucose/electrolyte solution and 27 (93%) of 29 infants given sugar/salt were successfully rehydrated with similar improvement in metabolic acidosis and rapidity of rehydration. The drawbacks to oral therapy with simple sugar/salt solution were the frequent development of hypokalaemia and greater volume of vomiting during treatment. Carefully prepared sugar/salt solution, if accompanied by adequate potassium supplementation, may be used as an alternative to the preferred glucose/electrolyte formula when the latter is unavailable.
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