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  • Title: The pathophysiology of angina pectoris and the effect of lidoflazine.
    Author: Gobel FL, Nordstrom LA, Nelson RR, Wang Y.
    Journal: Circulation; 1982 Jan; 65(1 Pt 2):I27-32. PubMed ID: 7030519.
    Abstract:
    Angina pectoris results from a deficiency in myocardial oxygen supply. The rate-pressure product is an important predictor of myocardial oxygen requirements in patients with ischemic heart disease and in normal persons. The rate-pressure product at the onset of angina pectoris is reproducible under a variety of circumstances with a suitable protocol. In some patients, coronary artery spasm may reduce myocardial blood flow and contribute to the development of angina pectoris. Lidoflazine is a synthetic drug that appears to be a calcium-entry blocker and results in symptomatic improvement in patients with angina pectoris. Lidoflazine reduces the exercising rate-pressure product by its effect on heart rate and by decreasing systemic vascular resistance. It decreases coronary vascular resistance and antagonizes processes leading to an increase in coronary vasomotor tone.
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