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  • Title: Effect of antihypertensive drugs on plasma renin activity and urinary excretion of prostaglandin E2.
    Author: Blum M, Algueti A, Bauminger S, Aviram A, Ayalon D.
    Journal: Prostaglandins Med; 1981 Oct; 7(4):261-6. PubMed ID: 7031725.
    Abstract:
    Urinary prostaglandin (PGE2) and plasma renin activity (PRA) were determined in 3 groups of hypertensive patients before and following 5 days of treatment with different antihypertensive drugs. In all 3 groups studied a substantial decrease of blood pressure was noted following treatment. However, whereas administration of chlorthalidone and hydralazine initiated a significant rise of PGE2 and PRA excretion, treatment with propranolol was associated with a decrease of these two parameters. In view of these findings it seems therefore as if renal production of PGE2 (at least with regard to propranolol, a beta-blocking agent), is not related to the hypotensive effect of the drug.
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