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  • Title: [Treatment of severe aplastic anemia].
    Author: Gratwohl A, Osterwalder B, Nissen C, Leibundgut U, Signer E, Lüthy A, Jeannet M, Speck B.
    Journal: Schweiz Med Wochenschr; 1981 Oct 10; 111(41):1520-2. PubMed ID: 7031870.
    Abstract:
    58 patients with severe aplastic anemia (SAA) were treated and evaluated in a prospective study either by bone marrow transplantation (BMT) or by antilymphocyte globulin (ALG). 19 patients were treated with BMT; 9 are still alive 6 months to 5 years after BMT (47%). 39 patients were treated with ALG; 28 are alive 5 months to 5 years after ALG (72%). 24 of these 28 are self-sustaining and in remission. The results show that treatment with ALG is probably superior to treatment with BMT, and also demonstrate that most patients with SAA have a pool of hematopoietic stem cells able to repopulate the marrow after this type of treatment.
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