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  • Title: The in vitro inhibitory effect on thrombin by 2,3-diphosphoglycerate.
    Author: Del Principe D, Strappini PM, Del Vecchio S, Menichelli A, Biancini G, Cosmi EV, Bastianon V, D'Arcangelo C.
    Journal: Thromb Haemost; 1981 Oct; 46(3):581-3. PubMed ID: 7031980.
    Abstract:
    Thrombin incubated with 2,3-diphosphoglycerate (150 nmol 2,3-DPG/1 NIH thrombin unit) lost up to 70% of its clotting activity, whereas the esterase activity remained unchanged. No fibrinopeptide release by thrombin was observed in the presence of 2,3-DPG. The fibrin polymerization was normal. By chromatography on Amberlite IRC-50, alpha-thrombin was eluted at pH 8.0. In presence of 2,3-DPG, alpha-thrombin was not eluted. Likely, 2,3-DPG can interfere with thrombin.
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