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  • Title: Clinical and histologic indications for extensive pancreatic resection in nesidioblastosis.
    Author: Kramer JL, Bell MJ, DeSchryver K, Bower RJ, Ternberg JL, White NH.
    Journal: Am J Surg; 1982 Jan; 143(1):116-9. PubMed ID: 7032331.
    Abstract:
    Nine children with nesidioblastosis underwent pancreatic resection at St. Louis Children's Hospital. Four of these underwent 99 percent of near-total resection. Only one child required permanent insulin therapy postoperatively. Pathologic examination of the resected pancreases revealed a diffuse disturbance of the pancreatic architecture. Prolonged hypoglycemia can have devastating neurologic sequelae. Based on clinical experience and the pathologic demonstration of a diffuse process in the affected pancreas, it is advocated that near-total (99 percent) pancreatectomy is the primary procedure of choice for this disease.
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