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  • Title: Beneficial effects of an anabolic steroid during cytotoxic chemotherapy for metastatic cancer.
    Author: Spiers AS, DeVita SF, Allar MJ, Richards S, Sedransk N.
    Journal: J Med; 1981; 12(6):433-45. PubMed ID: 7033426.
    Abstract:
    To investigate the effects of concurrent administration of an anabolic steroid upon hematopoiesis and metabolism in patients with cancer who were receiving cytotoxic chemotherapy, a randomized trial was conducted. Thirty-three evaluable patients received intensive multiple-agent chemotherapy: 17 received in addition nandrolone decanoate ("Deca-Durabolin"), 200 mg intramuscularly each week. The nandrolone-treated patients showed significantly better maintenance of hemoglobin concentrations and body weight, and a highly significant reduction in number of blood transfusions. Improved survival in the androgen-treated patients did not achieve significance. There were no differences in neutrophil or platelet counts or in tolerance of cytotoxic drugs. Toxicity from nandrolone therapy was minimal.
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