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  • Title: Primary structure of an unusual glycine tRNA UGA suppressor.
    Author: Prather NE, Murgola EJ, Mims BH.
    Journal: Nucleic Acids Res; 1981 Dec 11; 9(23):6421-8. PubMed ID: 7033934.
    Abstract:
    We have determined the nucleotide sequences of two UGA-suppressing glycine transfer RNAs. The suppressor tRNAs were previously shown to translate both UGA and UGG and to have arisen as a consequence of mutation in glyT, the gene for the GGA/G-reading glycine tRNA of Escherichia coli. In each mutant tRNA, the primary sequence change was the substitution of adenine for cytosine in the 3' position of the anticodon. In addition, a portion of mutant glyT tRNA molecules contained N6-(delta 2-isopentenyl)-2-thiomethyl adenine adjacent to the 3' end of the anticodon (nucleotide 37). The presence or absence of this hypermodification may be a determinant in some of the biological properties of the mutant tRNA.
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