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  • Title: Relapse of duodenal ulcer after treatment with trimipramine/antacids or cimetidine/antacids.
    Author: Berstad A, Aadland E, Bjerke K, Carlsen E.
    Journal: Scand J Gastroenterol; 1981; 16(7):933-6. PubMed ID: 7034164.
    Abstract:
    Ninety-three patients with duodenal ulcer were treated with trimipramine, 25 mg at night; cimetidine, 400 mg at night; or cimetidine, 1000 mg/day. In addition, all patients were given 20 ml antacids 1 and 3 h after meals. The healing rates after 6 weeks' treatment were 86%, 85%, and 100% in the three groups, respectively (differences not significant). After healing of the ulcers 88 of the patients were checked monthly during 1 year to study relapse rate. Endoscopy was performed on recurrence of symptoms suggesting relapse and after 6 and 12 months in all asymptomatic patients. Relapse was diagnosed in 64% of the patients in the trimipramine-treated group, in 48% in the 400 mg cimetidine group, and in 54% in th 1000 mg cimetidine group (differences not significant). The results suggest that ulcer recurrence is not commoner after treatment with standard dose of cimetidine than after a low dosage of cimetidine or trimipramine.
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