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  • Title: Regulation of granulopoiesis and distribution of granulocytes in early phase of bacterial infection.
    Author: Hartmann DW, Entringer MA, Robinson WA, Vasil ML, Drebing CJ, Morton NJ, True L.
    Journal: J Cell Physiol; 1981 Oct; 109(1):17-24. PubMed ID: 7035470.
    Abstract:
    Studies have been carried out to determine the effect of bacterial infection on CSF production, CFU-C activation, and bacterial clearance by mature granulocytes in mice infected with Escherichia coli. These studies have shown that immediately after bacterial infection (5 minutes), serum colony-stimulating factor (CSF) levels and bone marrow colony-forming units in culture (CFU-C) levels are elevated. This is followed by oscillatory rises in both of these parameters and the appearance of granulocytes in the infected site. With clearance of bacteria, CSF and CFU-C levels return to normal. These studies have indicated further that bacterial infection is a major stimulus for granulocyte production through the CSF-CFU-C system and that clearance of bacteria by mature granulocytes may serve as a negative feedback regulatory arm.
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