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  • Title: A comparison of the response to 4CMB, 4HMB and BC of 5 yeast strains differing in their radiosensitivities.
    Author: North TA, Parry JM.
    Journal: Mutat Res; 1982; 100(1-4):113-7. PubMed ID: 7035878.
    Abstract:
    The test compounds 4CMB, 4HMB and BC were assayed for their genotoxicity using stationary phase cultures of 5 yeast strains which differ in their mutagen sensitivity. It was found that 4HMB produced no differences in survival between the 5 strains whereas 4CMB and BC caused more lethality in the triple red strain than the other 4 strains. The results indicate that both BC and 4CMB are capable of inducing DNA damage which results in cell lethality in the repair-deficient triple mutant.
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