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  • Title: UKEMS trial: bacterial mutation tests of 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl, and benzyl chloride, using E. coli WP2uvrA(pKM101) and S. typhimurium TA98 and TA100.
    Author: Venitt S, Crofton-Sleigh C, Bosworth DA.
    Journal: Mutat Res; 1982; 100(1-4):39-43. PubMed ID: 7035896.
    Abstract:
    4CMB, 4HMB and BC were assayed in plate tests, using E. coli WP2urvA(pKM101), and S. typhimurium TA98 and TA100, in the presence or absence of microsomal activation. 4CMB was also assayed in fluctuation tests using E. coli WP2uvrA(pKM101). 4HMB was uniformly negative, and 4CMB was mutagenic to all 3 strains. BC was negative in TA98 and positive in TA100 and WP2uvrA(pKM101). The presence of absence of S9 made no substantial difference to the mutagenicity of 4CMB or BC.
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