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  • Title: 'Nephrotoxicity' and metabolic acidosis in transplant patients on cyclosporin A.
    Author: Hamilton DV, Evans DB, Henderson RG, Thiru S, Calne RY, White DJ, Carmichael DJ.
    Journal: Proc Eur Dial Transplant Assoc; 1981; 18():400-9. PubMed ID: 7036160.
    Abstract:
    Renal function, as represented by serum creatinine and creatinine clearance, 18 to 24 months after renal transplantation was studied in 21 patients receiving Cyclosporin A and compared with that of 25 patients on corticosteroids and azathioprine. Although renal function at six months post transplantation was significantly poorer in those patients on Cyclosporin A compared with those on conventional therapy, it did not deteriorate with time. No significant alteration in renal function was observed in five hepatic transplant recipients on Cyclosporin A after three months. Lower serum bicarbonate was observed more frequently in those renal transplant recipients on Cyclosporin A than in those on conventional therapy, reflecting possible tubular damage.
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