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  • Title: [LeuB24]- and [LeuB25]insulins are not antagonists of lipogenesis in adipocytes.
    Author: Diaconescu C, Saunders D, Gattner HG, Brandenburg D.
    Journal: Hoppe Seylers Z Physiol Chem; 1982 Feb; 363(2):187-92. PubMed ID: 7037593.
    Abstract:
    Semisynthetic human [LeuB24]-and [LeuB25]insulins were investigated to determine whether they show antagonistic properties towards insulin-stimulated lipogenesis in isolated fat cells. In contrast to other reports, we could detect only an additive agonistic effect when constant concentrations (e.g. 0.3 ng/ml) of the analogues were mixed with varying concentrations of insulin, or when constant concentrations (e.g. 0.3 ng/ml, 0.6 ng/ml) of insulin were mixed with varying concentrations of the analogues. Similar results were obtained with mixtures of insulin and NA2-acetyl- or NA2-propionyl-des-GlyA1-insulins. These results do not support the contention that a diabetic state could be caused by either of these mutant human insulins.
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