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  • Title: The mode of action of nosiheptide (multhiomycin) and the mechanism of resistance in the producing organism.
    Author: Cundliffe E, Thompson J.
    Journal: J Gen Microbiol; 1981 Sep; 126(1):185-92. PubMed ID: 7038038.
    Abstract:
    The mode of action of nosiheptide (multhiomycin) on bacterial protein synthesis is closely similar to that of thiostrepton. Both antibiotics inhibit functions of elongation factors Tu and G and greatly reduce the synthesis of guanosine penta- and tetraphosphates in response to stringent factor. Furthermore, the actinomycetes which produce these antibiotics defend themselves against their products in similar fashion. This involves specific pentose-methylation of 23S ribosomal RNA.
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