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  • Title: Key for protein coding sequences identification: computer analysis of codon strategy.
    Author: Rodier F, Gabarro-Arpa J, Ehrlich R, Reiss C.
    Journal: Nucleic Acids Res; 1982 Jan 11; 10(1):391-402. PubMed ID: 7038623.
    Abstract:
    The signal qualifying an AUG or GUG as an initiator in mRNAs processed by E. coli ribosomes is not found to be a systematic, literal homology sequence. In contrast, stability analysis reveals that initiators always occur within nucleic acid domains of low stability, for which a high A/U content is observed. Since no aminoacid selection pressure can be detected at N-termini of the proteins, the A/U enrichment results from a biased usage of the code degeneracy. A computer analysis is presented which allows easy detection of the codon strategy. N-terminal codons carry rather systematically A or U in third position, which suggests a mechanism for translation initiation and helps to detect protein coding sequences in sequenced DNA.
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