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  • Title: Idiopathic thrombocytopenic purpura in children; detection of platelet autoantibodies by immunofluorescence.
    Author: van Leeuwen EF, von dem Borne AE, van der Plas-van Dalen C, Engelfriet CP.
    Journal: Scand J Haematol; 1981 Apr; 26(4):285-91. PubMed ID: 7038843.
    Abstract:
    There are 3 varieties of idiopathic thrombocytopenic purpura (ITP) in children: the acute, the chronic and the recurrent forms. We have tested the platelets from 80 children with these forms of ITP by an immunofluorescence test. Platelet-bound immunoglobulins were detected in 19/22 acute, 41/48 chronic and 5/10 recurrent cases of ITP, i.e. in 65 of a total of 80 cases. A significance differences between acute and chronic ITP was found in the observation that only IgM was bound to the platelets of 7/16 patients with acute ITP. In all cases of chronic ITP with a positive direct immunofluorescence test, IgG was present on the platelet membrane. It is assumed because some patients with chronic ITP do not have elevated platelet-bound immunoglobulins, and show refractoriness to immunosuppressive therapy, that in these patients the disorder is not of a humoral autoimmune nature.
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