These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Distribution of fibronectin in fibrotic human livers at various states.
    Author: Kojima N, Isemura M, Yosizawa Z, Ono T, Shinada S, Soga K, Aoyagi Y, Ichida F.
    Journal: Tohoku J Exp Med; 1981 Dec; 135(4):403-12. PubMed ID: 7038987.
    Abstract:
    Fibronectin was isolated from human plasma by affinity chromatography with gelatin-coupled Sepharose 4B. Anti-fibronectin antiserum was prepared using rabbits, and human liver biopsy specimens at various stages of fibrosis were investigated for distribution of fibronectin by the indirect immunofluorescence technique. Fibronectin was absent in liver parenchymal cells, while it was detected markedly in reticulin and the area containing collagen fibers. The existence of fibronectin in the necrotic area and in prematured fibers suggests the earlier deposition of fibronectin than that of collagen at the locus of tissue repairing, and thus the important role of fibronectin at the early stage of fibrosis.
    [Abstract] [Full Text] [Related] [New Search]