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  • Title: Effects of angiotensin II on blood pressure, plasma renin activity, and aldosterone in the fetal lamb.
    Author: Siegel SR, Oaks G, Palmer S.
    Journal: Dev Pharmacol Ther; 1981; 3(3):144-9. PubMed ID: 7040002.
    Abstract:
    11 chronically catheterized fetal lamb preparations between 102 and 138 days of gestation (term 140--150 days) were studied after a continuous infusion of exogenous angiotensin II (0.25 microgram/kg/min). The pressor response to angiotensin II was delta 12.4 +/- 1.1 mm Hg. Plasma renin activity decreased from 6.33 +/- 2.49 ng/ml/h (mean and SEM) to 3.08 +/- 1.21 (p less than 0.05) after 30 min of the angiotensin II infusion. Plasma aldosterone showed a small increase from 5.13 +/- 0.9 to 7.34 +/- 1.22 ng/dl after 60 min (p less than 0.05) of the angiotensin II infusion. These results indicate that a pressor dose of angiotensin II will inhibit plasma renin activity and stimulate aldosterone secretion during the last trimester in the fetal sheep.
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