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  • Title: Plasma glucose and insulin response to glucagon and arginine in Aston ob/ob mice: evidence for a selective defect in glucose-mediated insulin release.
    Author: Flatt PR, Bailey CJ.
    Journal: Horm Metab Res; 1982 Mar; 14(3):127-30. PubMed ID: 7040198.
    Abstract:
    Fed adult obese hyperglycaemic (ob/ob) mice fail to produce a positive plasma insulin response to an intraperitoneal (ip) glucose challenge. The present study demonstrates that both fed and fasted ob/ob mice produce a marked positive plasma insulin response to an ip challenge by glucagon or arginine throughout the phases of development and regression of the ob/ob syndrome. These observations provide evidence that failure of the B-cells to respond to glucose in fed adult ob/ob mice cannot be attributed to inadequate amounts of releasable insulin. In addition, the results show that the B-cells of fed adult ob/ob mice do not incur a generalized defect of stimulus-recognition-secretion-coupling.
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