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  • Title: Randomized clinical trial of perioperative cefoxitin in preventing maternal infection after primary cesarean section.
    Author: Polk BF, Krache M, Phillippe M, Muñoz A, Hutchinson D, Miao L, Schoenbaum SC.
    Journal: Am J Obstet Gynecol; 1982 Apr 15; 142(8):983-7. PubMed ID: 7041652.
    Abstract:
    To determine the efficacy of perioperative cefoxitin in preventing infections after primary cesarean section, a randomized placebo-controlled, double-blind clinical trial was performed. Among 266 participants, those who received three perioperative 2 gm doses of cefoxitin (138) had significantly fewer serious infections (19.5% vs. 4.3%), fewer urinary tract infections (10.7% vs. 4.4%), less standard febrile morbidity (9.4% vs. 3.6%), and fewer courses of antibiotics postoperatively (23.4% vs. 11.6%). There was no reduction in the length of hospitalization. Use of perioperative cefoxitin umbilical cord is clamped are safe and efficacious in preventing infection after primary cesarean section.
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