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  • Title: Potentiated immune responses after administration of aclacinomycin.
    Author: Orbach-Arbouys S, Andrade-Mena CE, Berardet M, Mathe G.
    Journal: Int Arch Allergy Appl Immunol; 1982; 68(2):117-21. PubMed ID: 7042586.
    Abstract:
    After the intraperitoneal injection of aclacinomycin into mice, a variety of immune responses were increased. The total plaque-forming spleen cell response to SRBC was higher in treated animals than in controls, in spite of an apparent cytotoxic effects on B cells. The aclacinomycin-sensitive cell is apparently a long-lived cell, surviving adult thymectomy. Delayed-type hypersensitivity reactions were also augmented in treated animals, particularly those bearing tumors. In adjuvant-treated mice, the injection of aclacinomycin augments the immune response still further. Such observations should be taken into account in the establishment of clinical protocols associating immunotherapy and chemotherapy.
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