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  • Title: Potentiation of antifungal effect of amphotericin B by squalene, an intermediate for sterol biosynthesis.
    Author: Masuda A, Akiyama S, Kuwano M, Ikekawa N.
    Journal: J Antibiot (Tokyo); 1982 Feb; 35(2):230-4. PubMed ID: 7042672.
    Abstract:
    The antifungal effect of a polyene antibiotic amphotericin B (AMB) was almost completely abrogated by exogenous addition of 0.1 microgram/ml ergosterol in the medium. The cytocidal effect of AMB on Saccharomyces cerevisiae was synergistically enhanced when cultured for more than 4 hours with squalene, an obligatory intermediate molecule for sterol formation. However, we could not find significant increase in cellular level of ergosterol content in the yeast cells fed with squalene.
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