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  • Title: Release of heat-labile enterotoxin subunits by Escherichia coli.
    Author: Yamamoto T, Yokota T.
    Journal: J Bacteriol; 1982 Jun; 150(3):1482-4. PubMed ID: 7042698.
    Abstract:
    Most of the heat-labile enterotoxin (LT) synthesized by Escherichia coli is cell associated; however, a small portion of LT (approximately 10%) is released by bacterial cells into the culture supernatant. The LT subunit B (LT-B) produced by a cloned LT-B gene (tox B) was released in amounts equal to the parent LT release. In contrast, no release of LT subunit A (LT-A) or its smaller derivatives was observed in strains containing cloned toxA genes. The data suggest that LT-B is necessary for the release of LT-A across the bacterial membrane.
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