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  • Title: A controlled study showing significant short term effect of prostaglandin E1 in healing of ischaemic ulcers of the lower limb in man.
    Author: Eklund AE, Eriksson G, Olsson AG.
    Journal: Prostaglandins Leukot Med; 1982 Mar; 8(3):265-71. PubMed ID: 7043494.
    Abstract:
    The effect on healing of ischaemic leg ulcers was tested in a double blind study in twenty-two patients given prostaglandin E1 intravenously. Ulcer shapes were determined regularly by stereophotogrammetry. A significant healing effect was found during the first weeks after prostaglandin E1 but not after placebo. After two months no significant difference was noted in ulcer size between the two groups which both had a wide range of ulcer size and type. In subjects receiving placebo 40 percent of the ulcers diminished. It is concluded that controlled studies are necessary because of the large variability in the development of ischaemic ulcers. Furthermore prostaglandin E1 must probably be given in higher dose and/or for longer time and/or more frequently than in the present study in order to show definite benefit over placebo.
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