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  • Title: Inhibition of acrosin by benzamidines.
    Author: Stürzebecher J.
    Journal: Acta Biol Med Ger; 1981; 40(10-11):1519-22. PubMed ID: 7044006.
    Abstract:
    Acrosin proved to be very susceptible to inhibition by benzamidine derivatives. Most of the inhibitors were at least 10-fold more potent against acrosin than against trypsin. The most potent inhibitors of acrosin of this series were amidinophenyl compounds with a keto group or a carbon amide moiety in the side chain. Comparison of the structure-activity relationships for the inhibition of acrosin and trypsin showed differences in the binding sites of both enzymes.
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