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  • Title: Chlorpromazine and propranolol extend survival of infant mice inoculated with enterotoxigenic Escherichia coli.
    Author: Bertin A.
    Journal: Ann Rech Vet; 1981; 12(2):137-41. PubMed ID: 7044258.
    Abstract:
    Effects of chlorpromazine and propranolol were tested in infant mice model of Enterotoxigenic Escherichia coli diarrhea. Reference strain B41 inoculated orally from 18 h to 48 h after birth causes death of almost all animals in less than 48 h. Both drugs, which are known to reverse submaximal induced secretion by heat-stable toxin in the suckling mouse assay, used as single treatment, were able to extend the survival of mice.
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