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  • Title: A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase.
    Author: Starzyk RM, Koontz SW, Schimmel P.
    Journal: Nature; 1982 Jul 08; 298(5870):136-40. PubMed ID: 7045689.
    Abstract:
    A covalent adduct of an aminoacyl tRNA synthetase and uracil nucleoside has been isolated. The enzyme adduct is catalytically inactive; one nucleoside is bound per catalytic site. The release of uridine restores enzyme activity. The nucleoside attaches to a protein segment required for tRNA interaction. The findings add support to concepts of a covalent component for some protein-nucleic acid complexes.
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