These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Histologic and hemodynamic effects of prostacyclin and prostaglandin E1 following oleic acid infusion.
    Author: Slotman GJ, Machiedo GW, Casey KF, Lyons MJ.
    Journal: Surgery; 1982 Jul; 92(1):93-9. PubMed ID: 7046123.
    Abstract:
    The hemodynamic and histologic effects of exogenous prostacyclin (PGI2) and prostaglandin E1 (PGE1) on oleic acid-induced acute respiratory failure were investigated. Adult mongrel dogs infused with oleic acid were treated with saline solution, PGE1, and PGI2. Significantly lowered blood pressure, systemic and pulmonary vascular resistance, and arteriovenous oxygen difference and preservation of preoleic cardiac output were observed in the pGI2 group. Compared with the saline group, only the arteriovenous oxygen difference was improved with PGE1. Light microscopy revealed acute edema and inflammation in the saline- and PGE1-treated lungs. Histologic specimens in the PGI2 group were normal.
    [Abstract] [Full Text] [Related] [New Search]