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  • Title: Mutagenicity of some indoles and related compounds in the Ames test.
    Author: Curvall M, Florin I, Jansson T.
    Journal: Toxicology; 1982; 23(1):1-10. PubMed ID: 7046138.
    Abstract:
    A series of indole derivatives and some analogues were tested for mutagenic activity using a histidine-requiring mutant of Salmonella typhimurium (TA 98). Quantitative tests were performed with and without addition of a liver fraction (S-9) from rats induced with Aroclor 1254. Three compounds, 2,3-dimethylindole, 2,3,5-trimethylindole and 2,3,6-trimethylindole, showed a mutagenic effect which was not increased on metabolic activation. The influence on the mutagenic activity of the number and positions of the substituents attached to the indole skeleton is discussed.
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