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  • Title: A double blind comparative study of mianserin and a fixed combination of amitriptyline plus chlordiazepoxide.
    Author: Dimitriou EC, Logothetis JA, Paschalidou M.
    Journal: Adv Biochem Psychopharmacol; 1982; 32():213-22. PubMed ID: 7046365.
    Abstract:
    A double-blind comparative trial was carried out in 64 depressed out-patients, comparing mianserin with a fixed combination of amitriptyline + chlordiazepoxide. Both preparations proved to be equally effective at the end of the trial, but the mianserin group showed a considerable therapeutic improvement at the end of the second week, in comparison to the other group. With regard to side-effects, mianserin produced by far less side-effects than the combination of amitriptyline + chlordiazepoxide. It was concluded that mianserin should be considered as one of the most suitable drugs for the treatment of depressed out-patients.
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