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  • Title: Decrease of tumor growth in mice after intravenous thymosin-treated bone marrow cell injection.
    Author: Cupissol D, Rey A, Goldstein AL, Serrou B.
    Journal: J Natl Cancer Inst; 1982 Jul; 69(1):27-31. PubMed ID: 7047833.
    Abstract:
    The effect of iv injection in C57BL/6 mice of 3X10(7) bone marrow cells preincubated in either thymosin fraction V or thymosin alpha-1 was evaluated on the growth of a 3-methylcholanthrene-induced transplantable tumor in a syngeneic system. The effect was then compared to that elicited by theophylline or levamisole, which both demonstrated thymosin-like action in vitro. The results showed significantly retarded tumor growth (P less than 0.001) and prolonged survival time (P less than 0.001) when thymosin fraction V was used. The same results were obtained with thymosin alpha-1 with use of the same protocol but only one-twentieth of the concentration of fraction V. Theophylline and levamisole demonstrated no antitumor effect.
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