These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mutagenicity of substituted carbazoles in Salmonella typhimurium.
    Author: LaVoie EJ, Briggs G, Bedenko V, Hoffmann D.
    Journal: Mutat Res; 1982 Apr; 101(2):141-50. PubMed ID: 7048081.
    Abstract:
    Mutagenic activities of 1-, 2-, 3-, 4-, and 9-methylcarbazole were evaluated in S. typhimurium TA1535, TA1537, TA1538, TA98, and TA100. Only 9-methylcarbazole was found to be mutagenic in S. typhimurium TA100 in the presence of rat-liver homogenate. Mutagenic activity was also observed in TA100 for 2,9-, 3,9-, and 4,9-dimethylcarbazole. None of these methylated carbazole derivatives was mutagenic in TA1535, TA1537, TA1538 and TA98 in either the presence of absence of rat-liver homogenate. These results indicate that a 9-methyl substituent is associated with the mutagenic activity of these carbazole derivatives. Comparative studies on the mutagenic activity of 9-substituted carbazoles demonstrated that the activity of 9-ethylcarbazole was less than that of 9-methylcarbazole. 9-Phenyl- and 9-i-propylcarbazole were inactive under identical assay conditions. 9-Hydroxymethylcarbazole, a major metabolite of 9-methylcarbazole, was confirmed to be a direct-acting mutagen in S. typhimurium TA100. 9-Formylcarbazole was inactive as a mutagen when assayed with or without metabolic activation. These data are consistent with the finding that 9-hydroxymethylcarbazole is a major proximate mutagenic form of 9-methylcarbazole.
    [Abstract] [Full Text] [Related] [New Search]